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KMID : 1040620160220020267
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Clinical and Molecular Hepatology
2016 Volume.22 No. 2 p.267 ~ p.271
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Bone marrow metastasis presenting as bicytopenia originating from hepatocellular carcinoma
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Hong Young-Mi
Yoon Ki-Tae
Cho Mong
Kang Dae-Hwan
Kim Hyung-Wook
Choi Cheol-Woong
Park Su-Bum
Heo Jeong
Woo Hyun-Young
Lim Won
SM Bakhtiar UI Islam
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Abstract
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The bone is a common site for metastasis in hepatocellular carcinoma (HCC). However, bone marrow metastasis from HCC is rarely reported, and its frequency is unclear. Here we report a rare case of bone marrow metastasis that presented as bicytopenia originating from HCC without bone metastasis. A 58-year-old man was admitted for investigation of a liver mass with extensive lymph node enlargement that was detected when examining his general weakness and weight loss. Laboratory findings revealed anemia, thrombocytopenia, mild elevated liver enzymes, normal prothrombin time percentage and high levels of tumor markers (α-fetoprotein and des-γ-carboxyprothrombin). Abdominal computed tomography showed multiple enhanced masses in the liver and multiple enlarged lymph nodes in the abdomen. A bone marrow biopsy revealed only a few normal hematopoietic cells and abundant tumor cells. Despite its rarity, bone marrow metastasis should always be suspected in HCC patients even if accompanied by cirrhosis.
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KEYWORD
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Carcinoma, Hepatocellular, Bone marrow, Metastasis
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